Publications

For the Public

  1. Environment, Chemicals and Disease: finding exposure triggers that cause Parkinson’s and other diseases. Strategic Discussions for Nebraska 2015
  2. SOT Communique. SOT 2018 Annual Meeting (by Carla Garza)
    http://toxchange.toxicology.org/p/bl/et/blogaid=2580
    http://toxchange.toxicology.org/p/bl/et/blogaid=2572

Representative publications

  1. Franco R, Cidlowski JA. Apoptosis & Glutathione: Beyond an antioxidant. Cell Death Differ. 2009;16(10):1303-14. https://www.ncbi.nlm.nih.gov/pubmed/19662025
  2. Franco R, Li S, Rodriguez-Rocha H, Burns M, Panayiotidis MI. Molecular Mechanisms of Pesticide-induced Neurotoxicity and Apoptosis: Relevance to Parkinson’s disease. Chem Biol Interact. 2010; 188(2):289-300. PMCID: PMC2942983. https://www.ncbi.nlm.nih.gov/pubmed/20542017
  3. Rodriguez-Rocha H, Garcia-Garcia A, Panayiotidis MI, Franco R. DNA damage and autophagy. Mutat Res. 2011; 711(1-2):158-66. PMCID: PMC3105359. https://www.ncbi.nlm.nih.gov/pubmed/21419786
  4. Garcia-Garcia A, Rodriguez-Rocha H, Madayiputhiya N, Pappa A, Panayiotidis MI, Franco R. Biomarkers of Protein Oxidation in Human Disease. Curr Mol Med. 2012; 12(6):681-97. https://www.ncbi.nlm.nih.gov/pubmed/22292436
  5. Garcia-Garcia A, Zavala-Flores L, Rodriguez-Rocha H, Franco R. Thiol-redox signaling, dopaminergic cell death and Parkinson's disease. Antioxid Redox Signal. 2012; 17(12):1764-84. PMCID: PMC3474187. https://www.ncbi.nlm.nih.gov/pubmed/22369136
  6. Franco R, Cidlowski JA. Glutathione efflux and cell death. Antioxid Redox Signal. 2012; 17(12):1694-713. PMCID: PMC3474185. https://www.ncbi.nlm.nih.gov/pubmed/22656858
  7. Rodriguez-Rocha H, Garcia-Garcia A, Zavala-Flores L, Li S, Madayiputhiya N, Franco R. Glutaredoxin 1 protects dopaminergic cells by increased protein glutathionylation in experimental Parkinson’s disease. Antioxid Redox Signal 2012; 17(12):1676-93. PMCID: PMC3474191. https://www.ncbi.nlm.nih.gov/pubmed/22816731
  8. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, …….Franco R, ……., Zorzano A, Zschocke J, Zuckerbraun B. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012; 8(4):445-544. PMCID: PMC3404883. https://www.ncbi.nlm.nih.gov/pubmed/22966490
  9. Rodriguez-Rocha H, Garcia-Garcia A, Pickett C, Li S, Jones J, Chen H, Webb B, Choi J, Zhou Y, Zimmerman M, Franco R. Compartmentalized oxidative stress in dopaminergic cell death induced by pesticides and complex I inhibitors: Distinct roles of superoxide anion and superoxide dismutases. Free Radic Biol Med. 2013; 61:370-83. PMCID: PMC3883883. https://www.ncbi.nlm.nih.gov/pubmed/23602909
  10. Garcia-Garcia A, Anandhan A, Burns M, Chen H, Zhou Y, Franco R. Impairment of Atg5-dependent autophagic flux promotes paraquat- and MPP+-induced apoptosis but not rotenone or 6-hydroxydopamine dopaminergic cell death. Toxicol Sci. 2013; 136(1):166-82. PMCID:  PMC3829573. https://www.ncbi.nlm.nih.gov/pubmed/23997112
  11. Navarro-Yepes, Zavala-Flores L, Anandhan A, Wang F, Skotak M, Chandra N, Li M, Pappa A, Martinez-Fong D, Del Razo LM, Quintanilla-Vega B, Franco R. Antioxidant gene therapy against neuronal cell death. Pharmacol Ther. 2014; 142(2):206-30. PMCID: PMC3959583. https://www.ncbi.nlm.nih.gov/pubmed/24333264
  12. Navarro-Yepes J, Burns M, Anandhan A, Khalimonchuk O, Del Razo LM, Quintanilla-Vega B, Pappa A, Panayiotidis MI, Franco R. Oxidative stress, redox signaling and autophagy: Cell death vs Survival. Antioxid Redox Signal. 2014; 21(1):66-85. PMCID: PMC4048575. https://www.ncbi.nlm.nih.gov/pubmed/24483238
  13. Wang F, Franco R, Skotak M, Hu G, Chandra N. Mechanical stretch exacerbates SH-SY5Y cell death induced by paraquat: mitochondrial dysfunction and oxidative stress.  Neurotoxicology. 2014; 41:54-63. PMCID: PMC3986102. https://www.ncbi.nlm.nih.gov/pubmed/24462953
  14. Lei S, Zavala-Flores L, Garcia-Garcia A, Nandakumar R, Madayiputhiya N, Huang Y, Stanton RC, Dodds ED, Powers R, Franco R. Alterations in energy/redox metabolism induced by mitochondrial and environmental toxins: A specific role for Glucose-6-Phosphate-Dehydrogenase and the Pentose Phosphate Pathway in Paraquat Toxicity. ACS Chem Biol. 2014; 9(9):2032-48. PMCID: PMC4168797. https://www.ncbi.nlm.nih.gov/pubmed/24937102
  15. Marshall D, Lei S, Worley B, Huang Y, Garcia-Garcia A, Franco R, Dodds ED, Powers R. Combining MS and NMR Datasets for Metabolomics Profiling. Metabolomics. 2015; 11:391-402. PMCID: PMC4354777. https://www.ncbi.nlm.nih.gov/pubmed/25774104
  16. Anandhan A, Rodriguez-Rocha H, Bohovych I, Griggs AM, Zavala-Flores L, Reyes-Reyes EM, Seravalli J, Stanciu LA, Lee J, Rochet JC, Khalimonchuk O, Franco R.  Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways. Neurobiol Dis. 2015; 81:76-92. PMCID: PMC4459946. https://www.ncbi.nlm.nih.gov/pubmed/25497688
  17. Klionsky DJ, …….Franco R, ……., Zughaier SM. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-22. PMCID: PMC4835977. https://www.ncbi.nlm.nih.gov/pubmed/26799652
  18. Navarro-Yepes J, Annandurai A, Bradley E, Bohovych I, Yarabe B, de Jong A, Ovaa H, Zhou Y, Khalimonchuk O, Quintanilla-Vega B, Franco R. Inhibition of protein ubiquitination by paraquat and 1-methyl-4-phenylpyridinium impairs ubiquitin-dependent protein degradation pathways. Mol Neurobiol. 2016; 53(8):5229-51.. PMCID: PMC4842169. https://www.ncbi.nlm.nih.gov/pubmed/26409479
  19. Klionsky DJ, …….Franco R, ……., Zughaier SM. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-22. PMCID: PMC4835977. https://www.ncbi.nlm.nih.gov/pubmed/26799652
  20. Anandhan A, Lei S, Levytskyy R, Pappa A, Panayiotidis MI, Cerny RL, Khalimonchuk O, Powers R, Franco R. Glucose metabolism and AMPK signaling regulate dopaminergic cell death induced by gene (α-synuclein)-environment (paraquat) interactions. Mol Neurobiol. 2017; 54(5):3825-3842 PMCID: PMC5173445. https://www.ncbi.nlm.nih.gov/pubmed/27324791
  21. Annadurai A, Jacome MS, Lei S, Hernandez-Franco P, Pappa A, Panayiotidis MI, Powers R, Franco R. Metabolic dysfunction in Parkinson’s disease: Bioenergetics, redox homeostasis and central carbon metabolism. Brain Res Bull. 2017; 133:12-30 PMCID: PMC5555796. https://www.ncbi.nlm.nih.gov/pubmed/28341600
  22. Powers R, Lei S, Annadurai Anandhan, Marshall DD, Worley B, Cerny RL, Dodds ED, Huang Y, Panayiotidis MI, Pappa P, Franco R. Metabolic investigations of molecular mechanisms associated with Parkinson’s disease. Metabolites. 24;7(2). pii: E22. PMCID: PMC5487993. https://www.ncbi.nlm.nih.gov/pubmed/28538683
  23. Rose J, Brian C, Woods J, Pappa A, Panayiotidis MI, Powers R, Franco R. Mitochondrial dysfunction in glial cells: Implications for neuronal homeostasis and survival. Toxicology. 2017; 391:109-115. PMCID: PMC5681369. https://www.ncbi.nlm.nih.gov/pubmed/28655545
  24. Garza-Lombó C, Posadas Y, Quintanar L, Gonsebatt ME, Franco R. Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress. Antioxid Redox Signal. 2018; 28(18):1669-1703. PMCID: PMC5962337. https://www.ncbi.nlm.nih.gov/pubmed/29402131
  25. Garza-Lombo C, Schroder A, Reyes-Reyes EM, Franco R. mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis and survival. Curr Opin Toxicol. 2018; 8:102-110 PMCID: PMC6223325. https://www.ncbi.nlm.nih.gov/pubmed/30417160
  26. Garza-Lombo C, Pappa A, Panayiotidis MI, Gonsebatt ME, Franco R. Arsenic-induced neurotoxicity: A mechanistic appraisal. J Biol Inorg Chem. 2019; 24(8):1305-1316 PMCID: PMC6903391. https://www.ncbi.nlm.nih.gov/pubmed/31748979
  27. Garza-Lombó C, Pappa A, Panayiotidis MI, Franco R. Redox Homeostasis, Oxidative Stress and Mitophagy. Mitochondrion. 2020; 51:105-117 PMCID: PMC7062406 https://pubmed.ncbi.nlm.nih.gov/31972372
  28. Sahoo BR, Pattnaik A, Annamalai AS, Franco R, Pattnaik AK. Mechanistic Target of Rapamycin (mTOR) Signaling Antagonizes Autophagy to Facilitate Zika Virus Replication. J Virol. 2020; 94(22):e01575-20 PMCID: PMC7592218 https://pubmed.ncbi.nlm.nih.gov/32878890
  29. Rose J, Brian C, Pappa A, Panayiotidis MI, Franco R. Mitochondrial Metabolism in Astrocytes Regulates Brain Bioenergetics, Neurotransmission and Redox Balance. Front Neurosci. 2020; 14:536682 PMCID: PMC7674659 https://pubmed.ncbi.nlm.nih.gov/33224019

Complete list of publications
Research ID Profile

https://researcherid.com/rid/D-9470-2013

Books

  1. Oxidative Stress and Redox Signalling in Parkinson’s Disease. Editors: Franco R, Rochet JC, Doorn JA. Issues in Toxicology (Book 34) Royal Society of Chemistry. 2017. 521 pages. ISBN-10: 1782621881; DOI: 10.1039/9781782622888. http://pubs.rsc.org/en/content/ebook/978-1-78262-188-1

Book Chapters (representative)

  1. Pasantes-Morales H, Franco R. Astrocyte Cellular Swelling: Mechanisms and Relevance to Brain Edema. In: The Role of Glia in Neurotoxicity. (Aschner M., Ed) 2005. CRC Press. Chapter 10 pp. 173 – 190
  2. Rodriguez-Rocha H, Garcia-Garcia A, Franco R. Biomarkers of Oxidative Stress in Carcinogenesis. In: Cancer Biomarkers. (Georgakilas A., Ed) 2012. CRC Press. Chapter 2 pp. 23-49
  3. Franco R, Zavala-Flores L. ABCC Transporter. In: Encyclopedia of Cancer: Springer Reference (www.springerreference.com). Schwab M. (Ed.) Springer-Verlag Berlin Heidelberg, 2012. DOI: 10.1007/SpringerReference_303443 2012-02-28 20:57:09 UTC
  4. Franco R, Garcia-Garcia A, Georgakilas AG, Pappa A, Panayiotidis MI. Oxidative Stress and Cancer. In: The Molecular Basis of Oxidative Stress: Chemistry, Mechanisms, and Disease Pathogenesis (Villamena E, Ed) 2013. Wiley. Chapter 9 pp. 203-239
  5. Annadurai A, Hernandez-Franco P, Franco R. Oxidative Stress, redox homeostasis and NF-κB signaling in neurodegeneration. In: The Oxidative Stress:  Diagnostics, Prevention and Therapy Volume 2. (Hepel M, Andreescu S Eds.). vol. 1200 American Chemical Society, 2015, pp 53-90.
  6. Hernandez-Franco P, Foguth R, Annadurai A, Franco R. Oxidative Stress and Redox Signaling in the Parkinson’s Disease Brain. In: Oxidative Stress and Redox Signaling in the Parkinson’s Disease Brain. (Franco R, Doorn JA, Rochet JC Eds.). 2017. Royal Society of Chemistry, UK. Chapter 2 pp. 27-60.
  7. Hernandez-Franco P, Annadurai A, Franco R. Protein Oxidation, Quality Control Mechanisms and Parkinson’s disease. In: Oxidative Stress and Redox Signaling in Parkinson’s Disease. (Franco R, Doorn JA, Rochet JC Eds.). 2017. Royal Society of Chemistry, UK. Chapter 10 pp. 277-234.

Guest Editor Special Issues

Cover of Mutant Research

Guest Editor. Special Issue in Oxidative Stress and Mechanisms of Environmental Toxicity. Published in: Mutation Research: Genetic Toxicology and Environmental Mutagenesis. Mutat Res. 2009; 674(1-2)

Cover of Chemico-Biological Interactions

Guest Editor. Special Issue in Cell Death or Survival: The Double Edge Sword of Environmental and Occupational Toxicity. Chem Biol Interact. 2010; 188(2)

Cover of ARS

Guest Editor. Forum Issue in Thiols in Cell Death. Antioxid Redox Signal 2012; 17(12)

Cover of ARS

Guest Editor. Forum Issue in Redox Metabolism and Signaling in Neurological Function, Dysfunction and Aging. Antioxid Redox Signal 2018; 28(18)

Cover of Toxicology April 2018

Guest Editor. Issue 8 in Metabolic Disruption in Environmental Diseases. Curr Opin Toxicol. 2018.