Welcome to Franco Laboratory

News & Events

 

  • Carla Garza will present the work titled “Autophagy: Friend or Foe in Arsenic-Induced Toxicity?” at the Society of Toxicology 2018 Annual meeting (March 11-15, San Antonio TX) within the Symposium titled: Mechanisms of Autophagic Function and Dysfunction in Neurotoxicity and Neurodegeneration

  • Dr. Franco becomes Editorial Board Member for the International Journal of Environmental Research and Public Health

  • The Book titled “Oxidative Stress and Redox Signalling in Parkinson’s Disease”, edited by Dr. Franco, Dr. Doorn and Dr. Rochet is published by the Royal Society of Chemistry.

  • Recent publication: Rose J, Brian C, Woods J, Pappa A, Panayiotidis MI, Powers R, Franco R. Mitochondrial Dysfunction in Glial Cells: Implications for Neuronal Homeostasis and Survival. Toxicology. (published)

  • Recent publication: Voulgaridou GP, Mantso T, Franco R, Panayiotidis M, Pappa A. Human Aldehyde Dehydrogenase 3A1 (ALDH3A1) exhibits chaperone-like function. Int J Biochem Cell Biol. 2017; 89:16-24.

  • Recent publication: Powers R, Lei S, Annadurai Anandhan, Marshall DD, Worley B, Cerny RL, Dodds ED, Huang Y, Panayiotidis MI, Pappa P, Franco R. Metabolic investigations of molecular mechanisms associated with Parkinson’s disease. Metabolites. 24;7(2). pii: E22. PMCID: PMC5487993

 

The Franco lab aims to understand the signaling mechanisms by which cellular metabolism, redox homeostasis and signaling regulate cellular fate. Mitochondrial dysfunction, alterations in protein quality control mechanisms and the activation/impairment of cell death pathways (apoptosis, necrosis and autophagy) have been associated with the etiology of human diseases. Energy failure and oxidative stress have been implicated in the induction of cell death, but the molecular mechanisms that link redox homeostasis and cellular metabolism to the activation of cell death pathways remain elusive. We strive to identify those mechanisms and provide and insight into potential therapeutic approaches. Our primary focus are neurotoxicity associated with environmental exposures, neurodegeneration, brain ischemia and cancer.

Rodrigo Franco

(Rodrigo Franco-Cruz)

Associate Professor
Dr. Rodrigo Franco
Dr. Rodrigo Franco