News & Events

 

  • Carla Garza participates in the SOT Reporter program
    http://toxchange.toxicology.org/p/bl/et/blogaid=2580
    http://toxchange.toxicology.org/p/bl/et/blogaid=2572

  • Dr. Franco becomes member of the American Association for the Advancement of Science (AAAS)

  • Dr. Franco guest edits the Forum Issue in Redox Metabolism and Signaling in Neurological Function, Dysfunction and Aging. Antioxid Redox Signal 2018; 28(18)

  • Dr. Franco guest edits Issue 8 on Metabolic Disruption in Environmental Diseases. Curr Opin Toxicol. 2018.

  • Recent publication: Garza-Lombo C, Posadas Y, Quintanar L, Gonsebatt ME, Franco R. Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress. Antioxid Redox Signal. 2018; 28(18):1669-1703.

  • Recent publication: Garza-Lombo C, Schroder A, Reyes-Reyes EM, Franco R. mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis and survival. Curr Opin Toxicol. (accepted)

  • Recent publication: Hernández-Franco P, Silva M, Franco R, Valverde M, Rojas E. Lead facilitates foci formation in a Balb/c-3T3 two-step cell transformation model: role of Ape1 function. Environ Sci Pollut Res Int. 2018; 25(12):12150-12158.

 

The Franco lab aims to understand the signaling mechanisms by which cellular metabolism, redox homeostasis and signaling regulate cellular fate. Mitochondrial dysfunction, alterations in protein quality control mechanisms and the activation/impairment of cell death pathways (apoptosis, necrosis and autophagy) have been associated with the etiology of human diseases. Energy failure and oxidative stress have been implicated in the induction of cell death, but the molecular mechanisms that link redox homeostasis and cellular metabolism to the activation of cell death pathways remain elusive. We strive to identify those mechanisms and provide and insight into potential therapeutic approaches. Our primary focus are neurotoxicity associated with environmental exposures, neurodegeneration, brain ischemia and cancer.

Rodrigo Franco

(Rodrigo Franco-Cruz)

Associate Professor
Dr. Rodrigo Franco
Dr. Rodrigo Franco