Welcome to Franco Laboratory



The Franco lab aims to understand the signaling mechanisms by which reactive oxygen species (ROS) regulate cellular fate. Distinct cell death pathways (apoptosis, necrosis and autophagy) have been associated to the etiology of human diseases such as cancer and neurodegeneration. ROS accumulation and oxidative stress have been implicated in the induction of cell death, but the molecular mechanisms that link ROS and the activation of cell death pathways remain elusive. We strive to identify those mechanisms and provide and insight into potential therapeutic approaches.

Rodrigo Franco

(Rodrigo Franco-Cruz)

Associate Professor
Dr. Rodrigo Franco
Dr. Rodrigo Franco

News & Events




  • Recent publication: Anandhan A, Lei S, Levytskyy R, Pappa A, Panayiotidis MI, Cerny RL, Khalimonchuk O, Powers R, Franco R. Glucose metabolism and AMPK signaling regulate dopaminergic cell death induced by gene (α-synuclein)-environment (paraquat) interactions. Mol Neurobiol. (accepted)

  • Recent publication: Annadurai A, Hernandez-Franco P, Franco R. Oxidative Stress, redox homeostasis and NF-κB signaling in neurodegeneration. In: The Oxidative Stress: Diagnostics, Prevention and Therapy Volume 2. (Hepel M, Andreescu S Eds.). vol. 1200 American Chemical Society, 2015, pp 53-90.

  • Recent publication: Klionsky DJ, …….Franco R. ……., Zughaier SM. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-22

  • Recent publication: Mantso T, Goussetis G, Franco R., Botaitis S, Pappa A, Panayiotidis M. Effects of hyperthermia as a mitigation strategy in DNA damage-based cancer therapies. Semin Cancer Biol. (accepted)

  • Dr. Franco will participate as part of the Scientific Committee for the XIV International Congress of Toxicology (IUTOX) in Mérida, Yucatán, Mexico, from 2-6 of October, 2016. “Toxicology and Global sustainability”. He will chair the Symposium titled: Environmental exposures and Neurotoxicity: Molecular mechanisms, epidemiology and risk assessment.