The Franco lab aims to understand the signaling mechanisms by which reactive oxygen species (ROS) regulate cellular fate. Distinct cell death pathways (apoptosis, necrosis and autophagy) have been associated to the etiology of human diseases such as cancer and neurodegeneration. ROS accumulation and oxidative stress have been implicated in the induction of cell death, but the molecular mechanisms that link ROS and the activation of cell death pathways remain elusive. We strive to identify those mechanisms and provide and insight into potential therapeutic approaches.
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Assistant Professor, School of Veterinary Medicine and Biomedical Sciences
Redox Biology Center (RBC)
Redox signaling with an emphasis in thiol-redox homeostasis and oxidative protein cysteine modifications
Cell death pathways regulated by oxidative stress and redox signaling including apoptosis, autophagy and necrosis
Neuronal cell death associated with neurodegenerative disorders, ischaemia and brain injury
Education & Training
1996-2000. National University of Mexico (UNAM). School of Sciences. B. S. in Biology
2000-2004. National University of Mexico (UNAM). Cell Physiology Institute. Ph.D. in Sciences (Biomedical sciences) Advisor: Prof. Herminia Pasantes Morales
2004-2009. Postdoctoral Fellow. Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH. Research Triangle Park, NC 27709. Supervisor: Dr. John A. Cidlowski
Awards, Fellowships and Recognitions
2001 and 2003. Young Investigator Travel Award. International Society for Neurochemistry (ISN)
2001. Basic Neurochemistry School (Scholarship). International Society for Neurochemistry.
2002. Young Investigator Travel Award. American Society for Neurochemistry (ASN)
2005. Marie Curie Scholarship. European Cell Death Organization
2007 and 2009. Travel Award. American Society of Biochemistry and Molecular Biology (ASBMB). Experimental Biology
2007 Martin Rodbell Travel Award, National Institutes of Environmental Health Sciences, National Institutes of Health
2008 Travel Award. Keystone Symposia Scholarship. Cell Death in the Immune System.
2009. Travel Award. American Society of Biochemistry and Molecular Biology (ASBMB). Experimental Biology
2006-present. National Program of Researchers (SNI) Level II. CONACYT, Mexico
2010. Layman Award. Office of Research. University of Nebraska-Lincoln
2014 SIGMA XI Outstanding Young Scientist Award (University of Nebraska Chapter)
2009-present. Active Member of the Society for Free Radical Biology and Medicine
2012-present. Regular Member of the Society for Neuroscience
2013-present. Full Member of the Society of Toxicology
2009-present. Editorial Board. Toxicology Mechanisms and Methods.
2011-present. Editorial Board. Chemico-Biological Interactions.
Other professional experience
2003-2004. Teaching Professor in Physiology. Bachelor in Biology Program. School of Sciences. Universidad Nacional Autonoma de Mexico. Av. Insurgentes Sur 3000, Circuito Exterior. Ciudad Universitaria, Mexico D.F. C.P. 04510.
2001 Visiting Scientist. Biochemical Department. August Krogh Institute, University of Copenhaguen, Copenhaguen, Denmark.
2009. Principal Investigator. Department of Toxicology. Center of Advanced Studies and Research of the National Polytechnic Institute (CINVESTAV). Mexico City, D.F. Mexico.