The Franco lab aims to understand the signaling mechanisms by which reactive oxygen species (ROS) regulate cellular fate. Distinct cell death pathways (apoptosis, necrosis and autophagy) have been associated to the etiology of human diseases such as cancer and neurodegeneration. ROS accumulation and oxidative stress have been implicated in the induction of cell death, but the molecular mechanisms that link ROS and the activation of cell death pathways remain elusive. We strive to identify those mechanisms and provide and insight into potential therapeutic approaches.
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